VOLUME 1, ISSUE 3, JANUARY2023

Abstract :- Natural resources like medicinal plants have been used traditionally to treat or manage various diseases and disorders. Cleome species possess to have major bioactive compounds with clinical significance. The present study was carried out to exploit the Cleome rutidosperma for its phytoconstituents and to isolate major bioactive compounds and their efficacy as cytotoxic agent against MCF-7 breast cancer cells. The isolated compound was characterized with GC-MS spectroscopy and the structure was elucidated using spectral data analysis which revealed the presence of a cardiac glycosides derivative that was isolated for the first time from Cleome rutidosperma namely Acetic acid 3, 14-dihydroxy-10,13-dimethyl-17-(6-oxo-6H-pyran-3-yl)-hexadecahydro- phenanthren-16-yl ester (Bufotalin). The crude and isolated Bufotalin possess to have potential anticancer activity with an IC50 value of 22.86 µg/ml and 3.895µg/ml respectively, against the breast cancer cell lines. The plant-mediated isolated cardiac glycoside bufotalin will be a potential agent for the control of the proliferation of cancer cells

Author :- MULLAI NILA K , KARTHIKEYAN J
Email:- jaaykay@gmail.com

DOI :     https://doi.org/10.59143/isas.jisas.1.3.QRKB3030

           Pages :- 15-32